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Publication
Recent Insights into Kidney Injury and Repair from Transcriptomic Analyses.
Authors Kirita Y, Chang-Panesso M, Humphreys BD
Submitted By Submitted Externally on 5/28/2020
Status Published
Journal Nephron
Year 2019
Date Published
Volume : Pages 143 : 162 - 165
PubMed Reference 31112966
Abstract Injured tubular epithelium exhibits cellular plasticity in that it can
dedifferentiate, reenter the cell cycle, and subsequently either redifferentiate
or adopt a chronically injured phenotype. Although some nephrogenic genes are
reexpressed during injury and repair, developmental pathways are only partially
recapitulated and the process is more accurately viewed as an entirely new
program intrinsic to the regenerative response to injury. Recent advances in our
understanding of the molecular circuitry underpinning epithelial plasticity have
come from bulk, cell-specific, and single-cell transcriptomic analyses. These
results have begun to define the signaling pathways and gene regulatory networks
governing the epithelial injury response. In this review, we highlight recent
transcriptomic analyses in kidney injury, repair and fibrosis, and outline the
ways that these studies are improving our understanding of kidney regeneration.




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