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Effect of pore size and spacing on neovascularization of a biodegradble shape
memory polymer perivascular wrap.
Boire TC, Himmel LE, Yu F, Guth CM, Dollinger BR, Werfel TA, Balikov DA, Duvall
Submitted Externally on 9/28/2020
Journal of biomedical materials research. Part A, REFERENCES
Volume : Pages
Neointimal hyperplasia (NH) is a main source of failures in arteriovenous
fistulas and vascular grafts. Several studies have demonstrated the promise of
perivascular wraps to reduce NH via promotion of adventitial neovascularization
and providing mechanical support. Limited clinical success thus far may be due
to inappropriate material selection (e.g., nondegradable, too stiff) and
geometric design (e.g., pore size and spacing, diameter). The influence of pore
size and spacing on implant neovascularization is investigated here for a new
biodegradable, thermoresponsive shape memory polymer (SMP) perivascular wrap.
Following an initial pilot, 21 mice were each implanted with six scaffolds: four
candidate SMP macroporous designs (a-d), a nonporous SMP control (e), and
microporous GORETEX (f). Mice were sacrificed after 4 (N =?5), 14 (N =?8), and
28 (N =?8) days. There was a statistically significant increase in
neovascularization score between all macroporous groups compared to nonporous
SMP (p .023) and microporous GORETEX (p .007) controls at Day 28.
Wider-spaced, smaller-sized pore designs (223?µm-spaced, 640?µm-diameter Design
c) induced the most robust angiogenic response, with greater microvessel number
(p .0114) and area (p .0055) than nonporous SMPs and GORETEX at Day 28. This
design also produced significantly greater microvessel density than nonporous
SMPs (p =?0.0028) and a smaller-spaced, larger-sized pore (155?µm-spaced,
1,180?µm-sized Design b) design (p =?.0013). Strong neovascularization is
expected to reduce NH, motivating further investigation of this SMP wrap with
controlled pore spacing and size in more advanced arteriovenous models.
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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