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Effect of pore size and spacing on neovascularization of a biodegradble shape
memory polymer perivascular wrap.
Authors Boire TC, Himmel LE, Yu F, Guth CM, Dollinger BR, Werfel TA, Balikov DA, Duvall
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Journal of biomedical materials research. Part A, REFERENCES
Year 2020
Date Published 6/1/2020
Volume : Pages Not Specified : Not Specified
PubMed Reference 32490564
Abstract Neointimal hyperplasia (NH) is a main source of failures in arteriovenous
fistulas and vascular grafts. Several studies have demonstrated the promise of
perivascular wraps to reduce NH via promotion of adventitial neovascularization
and providing mechanical support. Limited clinical success thus far may be due
to inappropriate material selection (e.g., nondegradable, too stiff) and
geometric design (e.g., pore size and spacing, diameter). The influence of pore
size and spacing on implant neovascularization is investigated here for a new
biodegradable, thermoresponsive shape memory polymer (SMP) perivascular wrap.
Following an initial pilot, 21 mice were each implanted with six scaffolds: four
candidate SMP macroporous designs (a-d), a nonporous SMP control (e), and
microporous GORETEX (f). Mice were sacrificed after 4 (N =?5), 14 (N =?8), and
28 (N =?8) days. There was a statistically significant increase in
neovascularization score between all macroporous groups compared to nonporous
SMP (p Wider-spaced, smaller-sized pore designs (223?µm-spaced, 640?µm-diameter Design
c) induced the most robust angiogenic response, with greater microvessel number
(p design also produced significantly greater microvessel density than nonporous
SMPs (p =?0.0028) and a smaller-spaced, larger-sized pore (155?µm-spaced,
1,180?µm-sized Design b) design (p =?.0013). Strong neovascularization is
expected to reduce NH, motivating further investigation of this SMP wrap with
controlled pore spacing and size in more advanced arteriovenous models.


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