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Publication
FATTY ACIDS AS CELL SIGNALS IN INGESTIVE BEHAVIORS.
Authors Figlewicz DP, Witkamp RF
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Physiology & behavior
Year 2020
Date Published 9/1/2020
Volume : Pages 223 : 112985
PubMed Reference 32473927
Abstract Common dietary fatty acids, including palmitic acid, stearic acid, oleic acid,
and polyunsaturated fatty acids, have been studied in the context of overall
dietary fat and shown to impact on several types of behaviors, most prominently
cognitive behaviors and ingestive behaviors. The independent effects of these
fatty acids have been less well-delineated. Several studies implicate these
common fatty acids in modulation of the CNS immune/inflammatory response as a
key mediator of behavioral effects. However, signaling actions of the fatty
acids to regulate cell structure and neuronal or synaptic function have been
identified in numerous studies, and the relevance or contribution(s) of these to
ingestive behavioral outcomes represent an area for future study. Finally, fatty
acids are precursors of endocannabinoids and their structural congeners. Being
highly dynamic and complex, the endocannabinoid system plays a key role
ingestive behavior via cellular and synaptic mechanisms, thus representing
another important area for future study.





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