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Publication
JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to
Feeding.
Authors DiTacchio KA, Kalinowska D, Saran AR, Byrne A, Vollmers C, DiTacchio L
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Cell reports
Year 2020
Date Published 5/1/2020
Volume : Pages 31 : 107668
PubMed Reference 32460011
Abstract The liver is a key regulator of systemic energy homeostasis whose proper
function is dependent on the circadian clock. Here, we show that livers
deficient in the oscillator component JARID1a exhibit a dysregulation of genes
involved in energy metabolism. Importantly, we find that mice that lack hepatic
JARID1a have decreased lean body mass, decreased respiratory exchange ratios,
faster production of ketones, and increased glucose production in response to
fasting. Finally, we find that JARID1a loss compromises the response of the
hepatic transcriptome to nutrient availability. In all, ablation of hepatic
JARID1a disrupts the coordination of hepatic metabolic programs with whole-body
consequences.





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