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Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in
the Kidneys of Female Non-Obese Diabetic Mice Before Establishment of Diabetes.
Authors Walter DL, Benner SE, Oaks RJ, Thuma JR, Malgor R, Schwartz FL, Coschigano KT,
McCall KD
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Viral immunology
Year 2020
Date Published 9/1/2020
Volume : Pages 33 : 494 - 506
PubMed Reference 32352894
Abstract End-stage renal disease (ESRD) is described by four primary diagnoses, diabetes,
hypertension, glomerulonephritis, and cystic kidney disease, all of which have
viruses implicated as causative agents. Enteroviruses, such as coxsackievirus
(CV), are a common genus of viruses that have been implicated in both diabetes
and cystic kidney disease; however, little is known about how CVs cause kidney
injury and ESRD or predispose individuals with a genetic susceptibility to type
1 diabetes (T1D) to kidney injury. This study evaluated kidney injury resulting
from coxsackievirus B4 (CVB4) inoculation of non-obese diabetic (NOD) mice to
glean a better understanding of how viral exposure may predispose individuals
with a genetic susceptibility to T1D to kidney injury. The objectives were to
assess acute and chronic kidney damage in CVB4-inoculated NOD mice without
diabetes. Results indicated the presence of CVB4 RNA in the kidney for at least
14 days post-CVB4 inoculation and a coordinated pattern recognition receptor
response, but the absence of an immune response or cytotoxicity. CVB4-inoculated
NOD mice also had a higher propensity to develop an increase in mesangial area
17 weeks post-CVB4 inoculation. These studies identified initial gene expression
changes in the kidney resulting from CVB4 exposure that may predispose to ESRD.
Thus, this study provides an initial characterization of kidney injury resulting
from CVB4 inoculation of mice that are genetically susceptible to developing T1D
that may one day provide better therapeutic options and predictive measures for
patients who are at risk for developing kidney disease from T1D.


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