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Publication
Aerobic exercise training improves hepatic and muscle insulin sensitivity, but
reduces splanchnic glucose uptake in obese humans with type 2 diabetes.
Authors Gregory JM, Muldowney JA, Engelhardt BG, Tyree R, Marks-Shulman P, Silver HJ,
Donahue EP, Edgerton DS, Winnick JJ
Submitted By Submitted Externally on 9/28/2020
Status Published
Journal Nutrition & diabetes
Year 2019
Date Published 9/1/2019
Volume : Pages 9 : 25
PubMed Reference 31474750
Abstract Aerobic exercise training is known to have beneficial effects on whole-body
glucose metabolism in people with type 2 diabetes (T2D). The responses of the
liver to such training are less well understood. The purpose of this study was
to determine the effect of aerobic exercise training on splanchnic glucose
uptake (SGU) and insulin-mediated suppression of endogenous glucose production
(EGP) in obese subjects with T2D., Participants included 11 obese humans with
T2D, who underwent 15?±?2 weeks of aerobic exercise training (AEX; n?=?6) or
remained sedentary for 15?±?1 weeks (SED; n?=?5). After an initial screening
visit, each subject underwent an oral glucose load clamp and an
isoglycemic/two-step (20 and 40?mU/m2/min) hyperinsulinemic clamp (ISO-clamp) to
assess SGU and insulin-mediated suppression of EGP, respectively. After the
intervention period, both tests were repeated., In AEX, the ability of insulin
to suppress EGP was improved during both the low (69?±?9 and 80?±?6%
suppression; pre-post, respectively; p?suppression, respectively; p?improved muscle insulin sensitivity, SGU was reduced in AEX after training
(22.9?±?3.3 and 9.1?±?6.0?g pre-post in AEX, respectively; p?T2D subjects, exercise training improves whole-body glucose metabolism, in part,
by improving insulin-mediated suppression of EGP and enhancing muscle glucose
uptake, which occur despite reduced SGU during an oral glucose challenge.




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