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Publication
Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice.
Authors Gunder LC, Harvey I, Redd JR, Davis CS, Al-Tamimi A, Brooks SV, Bridges D
Submitted By Submitted Externally on 11/10/2020
Status Published
Journal Biomedicines
Year 2020
Date Published 10/1/2020
Volume : Pages 8 : Not Specified
PubMed Reference 33076257
Abstract Glucocorticoids promote muscle atrophy by inducing a class of proteins called
atrogenes, resulting in reductions in muscle size and strength. In this work, we
evaluated whether a mouse model with pre-existing diet-induced obesity had
altered glucocorticoid responsiveness. We observed that all animals treated with
the synthetic glucocorticoid dexamethasone had reduced strength, but that
obesity exacerbated this effect. These changes were concordant with more
pronounced reductions in muscle size, particularly in Type II muscle fibers, and
potentiated induction of atrogene expression in the obese mice relative to lean
mice. Furthermore, we show that the reductions in lean mass do not fully account
for the dexamethasone-induced insulin resistance observed in these mice.
Together, these data suggest that obesity potentiates glucocorticoid-induced
muscle atrophy.




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