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Nuclear envelope-vacuole contacts mitigate nuclear pore complex assembly stress.
Authors Lord CL, Wente SR
Submitted By Submitted Externally on 11/10/2020
Status Published
Journal The Journal of cell biology
Year 2020
Date Published 12/1/2020
Volume : Pages 219 : Not Specified
PubMed Reference 33053148
Abstract The intricacy of nuclear pore complex (NPC) biogenesis imposes risks of failure
that can cause defects in nuclear transport and nuclear envelope (NE)
morphology; however, cellular mechanisms used to alleviate NPC assembly stress
are not well defined. In the budding yeast Saccharomyces cerevisiae, we
demonstrate that NVJ1- and MDM1-enriched NE-vacuole contacts increase when NPC
assembly is compromised in several nup mutants, including nup116?GLFG cells.
These interorganelle nucleus-vacuole junctions (NVJs) cooperate with lipid
droplets to maintain viability and enhance NPC formation in assembly mutants.
Additionally, NVJs function with ATG1 to remodel the NE and promote
vacuole-dependent degradation of specific nucleoporins in nup116?GLFG cells.
Importantly, NVJs significantly improve the physiology of NPC assembly mutants,
despite having only negligible effects when NPC biogenesis is unperturbed. These
results therefore define how NE-vacuole interorganelle contacts coordinate
responses to mitigate deleterious cellular effects caused by disrupted NPC


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