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Exploring Key Physiological System Profiles at Rest and the Association with
Depressive Symptoms in Autism Spectrum Disorder.
Authors Muscatello RA, Andujar J, Taylor JL, Corbett BA
Submitted By Submitted Externally on 11/10/2020
Status Published
Journal Journal of autism and developmental disorders
Year 2020
Date Published 4/1/2020
Volume : Pages Not Specified : Not Specified
PubMed Reference 32350791
Abstract Depression is often associated with dysfunction in the
hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system (ANS).
Individuals with autism spectrum disorder (ASD) may experience physiological
dysregulation and psychological comorbidities; however, the extent to which the
interactions between these systems predict internalizing symptoms in ASD has not
been investigated. The study examined interactions with the HPA axis and ANS in
10-13-year-old children with ASD (n?=?41) and typical development (TD; n?=?46).
The interrelated systems uniquely contributed to depressive symptoms in ASD
above and beyond any system in isolation. A reciprocal, parasympathetic-dominant
ANS was related to fewer affective symptoms in ASD. Findings highlight the
importance of examining arousal across multiple systems to more precisely
identify profiles associated with maladaptive psychiatric outcomes in ASD.


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