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Strain
NOD.129S1(B6)-Ifngr2tm1Pbro/DvsJ

Summary Data Summary
Official Name NOD.129S1(B6)-Ifngr2tm1Pbro/DvsJ
Common Name NOD.IFNRBnull
Description A replacement vector of 11 kb including the Ifngr2 gene was
derived from a 129/Sv genomic library and the second exon
was replaced by a neomycin resistence cassette. After
transfection, correctly targeted W9.5 ES cells (derived from
129S1/Sv-p+ Tyr+ Kitl+) were injected into C57BL/6
blastocysts and resulting heterozygous chimeric mice were
intercrossed to create homozygous Ifngr2 deficient mice. The
disrupted Ifngr2 gene was then congenically transferred to
the NOD/Lt background using a marker assisted protocol.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1


Investigators
NameInstitution
Ricardo GazzinelliUniversity of Massachusetts Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Ifngr2knockoutknockoutNot Specified

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