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Strain
129S6/SvEv-Stat1tm1Rds/Tac

Summary Data Summary
Official Name 129S6/SvEv-Stat1tm1Rds/Tac
Common Name Stat1 KO
Description The Stat1 mouse was developed in the laboratory of Robert
Schreiber at the Washington University School of Medicine.
The model was created by targeting the Stat1 gene in GS-1 ES
cells and injecting the targeted cells into blastocysts.
Heterozygotes for the mutation were produced from the
chimeras and intercrossed to generate homozygotes. Taconic
received stock in 1997. The mice were embryo transfer
derived. The original Stat1 model (000679-M) differed from
the Taconic 129S6 at two biochemical loci, Pgm1 and Gpi1. In
January 2002, the original Stat1 line was backcrossed to the
Taconic 129S6/SvEvTac, and animals were selected to match
the Pgm1c and Gpi1b alleles of the 129S6. The selected
heterozygotes were intercrossed to homozygosity. The line is
maintained through incrossing of homozygous mice. This
improvement makes the 129S6/SvEvTac a more perfectly matched
control for the Stat1 model.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Breeding Generations 10
TypeCount
Investigators 1
Genomics - Modifications 1
Publications 1


Investigators
NameInstitution
Andrew LarnerVirginia Commonwealth University


Genomic Information
GeneAllele 1Allele 2Protocol
Stat1knockoutknockoutNot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes.
Sisler JD, Morgan M, Raje V, Grande RC, Derecka M, Meier J, Cantwell M, Szczepanek K, Korzun WJ, Lesnefsky EJ, Harris TE, Croniger CM, Larner AC
PLoS ONE, 2015 (10), e0144444
Submitted Externally
26689548
Published

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