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NCoR-omega and NCoR-delta share a splice acceptor but
utilize two distinct splice donors. Splice-specific NCoR
knockout mice were generated by the Mouse Biology Program at
the University of California at Davis (UC Davis). The
NCoR-omega splice donor was inactivated by site-directed
mutagenesis in mice without disrupting the NCoR-delta splice
donor or the NCoR-delta protein sequence to generate
NCoR-omega -/- mice.
A loxP site was inserted upstream of exon 38 and an FRT
flanked neomycin resistance cassette with a 5' loxP site was
inserted downstream of exon 41. Flp-mediated recombination
removed the selection cassette and left exons 38 through 41
floxed. Cre-mediated recombination removed exons 38 through
41, encoding two of the three receptor interacting domains
(N2 and N3).
Genomics - Modifications
University of California Davis
Curation Flag Information
New comment to be added:
Circulating corticosterone levels in Ncor1D mice
Circulating HDL-C and LDL-C levels in NCoR mice
Circulating lipids and inflammatory markers in NCoR mice
IPGTT insulin levels in NCoR KO mice
Liver TG, IRS1, Akt measurements in NCoR KO mice
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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