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Strain
B6.Cg-Cav1tm2Tt Tg(Vil1-Cre)997Gum

Summary Data Summary
Official Name B6.Cg-Cav1tm2Tt Tg(Vil1-Cre)997Gum
Common Name CAV1IEC-KO
Description Cav1 knockin: A loxP site flanked neomycin resistance gene
cassette was inserted into intron 1 and a third loxP site
into intron 2, creating a conditional-ready allele with a
floxed exon 2.

Villin-cre transgenic mice have the mouse villin 1 promoter
directing expression of Cre recombinase to villus and crypt
epithelial cells of the small and large intestines, in a
pattern that closely resembles endogenous Vil1 expression.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Publications 1


Investigators
NameInstitution
Steve FarberCarnegie Institute


Genomic Information
GeneAllele 1Allele 2Protocol
Cav1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedVil1CRENot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels.
Otis JP, Shen MC, Quinlivan V, Anderson JL, Farber SA
Disease models & mechanisms, 2017 (10), 283 - 295
Submitted Externally
28130355
Published

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