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Strain
B6.129X1-Becn1tm1Blev

Summary Data Summary
Official Name B6.129X1-Becn1tm1Blev
Common Name Atg6 -/-
Description beclin 1, autophagy related; MGI:1891828; NCBI Gene: 56208

Exons 1 and 2 were replace with a neomycin selection
cassette inserted by homologous recombination.
Development Status Phenotyping ongoing
Creation Method knockin
TypeCount
Investigators 1
Genomics - Modifications 1
Publications 1


Investigators
NameInstitution
Congcong HeNorthwestern University Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Becn1knockinknockinNot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C
PLoS genetics, 2017 (13), e1006962
Submitted Externally
28806762
Published

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