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Strain
B6.129S1-Mapk10tm1Flv

Summary Data Summary
Official Name B6.129S1-Mapk10tm1Flv
Common Name JNK3
Description mitogen-activated protein kinase 10; JNK3; MGI:1346863; NCBI
Gene: 26414

A neomycin resistance cassette replaced a genomic fragment
containing sequences corresponding to amino acids 211-267,
which encode the tripeptide dual phosphorylation motif
required for protein kinase activity. Northern blot and
RT-PCR analysis on total brain RNA derived from homozygous
mice demonstrated that no detectable transcript is produced
from this allele. Enzymatic activity assays on extracts
derived from hippocampus of homozygous mice confirmed that
no functional protein was expressed from this allele.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Publications 1


Investigators
NameInstitution
Roger DavisUniversity of Massachusetts Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Mapk10knockoutknockoutNot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.
Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ
eLife, 2016 (5), e10031
Submitted Externally
26910012
Published

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