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Strain
B6.Cg-Apoetm1Unc Soat1tm1Far Lyz2tm1(cre)Ifo

Summary Data Summary
Official Name B6.Cg-Apoetm1Unc Soat1tm1Far Lyz2tm1(cre)Ifo
Common Name Apoe-/- Acat1-M/-M
Description Acetyl-Coenzyme A acetyltransferase 1(Acat1) gene has been
floxed and crossed with a transgenic mouse with the Lyz2
promoter driving the Cre gene. The mouse also has the ApoE
gene globally knocked out.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 3
Publications 1


Investigators
NameInstitution
Ta-Yuan ChangDartmouth Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Acat1knockin (lox)knockin (lox)Not Specified
ApoeknockoutknockoutNot Specified
Lyz2knockin (Cre)wildNot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang TY
The Journal of biological chemistry, 2016 (291), 6232 - 44
Submitted Externally
26801614
Published

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