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Strain
129/Sv-Klkl

Summary Data Summary
Official Name 129/Sv-Klkl
Common Name Klotho KO -/+
Description This allele was discovered after mating and screening mice
that did not express an exogenous transgene (rabbit type-I
sodium-proton exchanger) in other work. One offspring from
these matings showed an interesting phenotype, and the
mutant was named klotho. It was determined that insertion of
the unrelated, exogenous transgene had caused an 8 kb
deletion in the 5' upstream region of the Kl locus in the
mutant animal.
Development Status Phenotyping ongoing
Creation Method transgenic
Breeding Generations 10
Phenotype Description Heterozygous mutant mice were used because they have half
the klotho expression levels seen in WT mice, which mimics
the decline in klotho levels associated with human aging.
Klotho homozygous mutants (KL-/-) were not used because they
demonstrate early and extensive aging phenotypes and die
before the age of 8 weeks.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
YI LINUniversity of Oklahoma Health Sciences Center


Genomic Information
GeneAllele 1Allele 2Protocol
KltransgenicwildNot Specified


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