mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Strain
B6.Cg-Soat1tm1Far Lyz2tm1(cre)Ifo

Summary Data Summary
Official Name B6.Cg-Soat1tm1Far Lyz2tm1(cre)Ifo
Common Name Acat1-M/-M
Description Soat1: Insertion of a neomycin cassette into a 5' early exon
(amino acids 50-100). Reduced levels of a truncated mRNA
transcript were detected by Northern blot on RNA from
preputial glands. No protein was detected by immunoblot
analysis in homogenates from preputial glands, ovaries and
adrenals.

Lyz2-cre: An NLS-cre gene was inserted into the endogenous
ATG start site of the gene. An frt-flanked neomycin cassette
was removed in ES cells via Flp-mediated recombination prior
to production of chimeric mice.
Development Status Phenotyping ongoing
Creation Method transgenic
Breeding Type intercross
Phenotype Description macrophage specific ACAT1 (also called SOAT1) gene KO mouse
is resistant to diet
induced obesity
TypeCount
Investigators 1
Genomics - Modifications 2
Genomics - Transgenes 1
Publications 1


Investigators
NameInstitution
Ta-Yuan ChangDartmouth Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Soat1knockoutknockoutNot Specified
Lyz2knockin (Cre)wildNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedLyz1CRENot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang TY
The Journal of biological chemistry, 2016 (291), 6232 - 44
Submitted Externally
26801614
Published

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.