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Strain
B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel

Summary Data Summary
Official Name B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel
Common Name B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel
Description SENP1+/lox mice were generated by inserting loxP sites
surrounding the SENP1 gene exons 5 and 6, based on
homologous recombination. SENP1lox/lox mice were obtained by
intercrossing SENP1+/lox mice. All mice had been
subsequently backcrossed onto the C57BL/6 background for
>6th generations. The deletion of SENP1 in adipocytes of
SENP1lox/lox:Cre was verified by quantitativePCR with
reverse transcription using primers amplifying exons 5–6 and
specific Cre. SENP1+/+:Cre and SENP1lox/lox mice used as
controls.

This transgene expresses Cre recombinase under the control
of a fatty acid binding protein 4, adipocyte (aP2) promoter.
Lines 1 and 2 were generated with different levels of
expression in brown and white adipose tissue. The pound
symbol (#) is used when no line is specified and/or lines
are pooled.
Development Status Phenotyping ongoing
Creation Method transgenic
Breeding Type backcross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Lan ShaoYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Senp1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedFabp4CRENot Specified


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