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Strain
B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J

Summary Data Summary
Official Name B6.129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J
Common Name TNFR1-/-R2-/- mice
Description TNFR1 KO: A PGK-neomycin resistance cassette replaced 4kb of
sequence, including exons 2 to 5 (amino acids 30 - 184).

TNFR2 KO:A PGK-neomycin resistance cassette replaced 1kb of
sequence encoding amino acids 3 - 26.

Mice homozygous for both the Tnfrsf1atm1Imx and
Tnfrsf1btm1Imx targeted mutations (p55 and p75 deficient)
are viable and fertile. Double homozygous mutant mice fail
to bind TNF. Thymus, spleen, and other lymphoid tissue are
normal, indicating that TNF is not required for normal
development of these organs.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 2
Experiments 1


Investigators
NameInstitution
ZHENQI SHIUniversity of Alabama at Birmingham


Genomic Information
GeneAllele 1Allele 2Protocol
Tnfrsf1aknockoutknockoutNot Specified
Tnfrsf1bknockoutknockoutNot Specified


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