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Strain
C57BL/6-Gt(ROSA)26Sortm1(ptxA)CghTg (adipoq-cre)1Evdr

Summary Data Summary
Official Name C57BL/6-Gt(ROSA)26Sortm1(ptxA)CghTg (adipoq-cre)1Evdr
Common Name C57BL/6-Gt(ROSA)26Sortm1(ptxA)CghTg (adipoq-cre)1Evdr
Description To generate mice lacking functional Gi proteins selectively
in adipocytes (“adipo-Gi KO mice”), we used
ROSA26-PTXflox/flox mice which contain the gene encoding the
catalytic subunit of PTX (S1-PTX), a known Gi signaling
inhibitor21,43. In this mouse strain, the S1-PTX coding
sequence is preceded by a flox-stop sequence. In order to
achieve selective expression of S1-PTX in adipocytes, we
crossed adipoq-Cre mice20 with ROSA26-PTXflox/flox mice.
Development Status Phenotyping ongoing
Creation Method transgenic
TypeCount
Investigators 1
Experiments 1


Investigators
NameInstitution
LEI WANGNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


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