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Catalog Item
Chronic high-fat/high sugar diet feeding
Common Name(s): Chronic high-fat feeding

CenterUniversity of California Davis
Center CoreAnimal Core
Test No.D2007
Test PriceInquire – Contact UCD Animal Care Core
DescriptionAn experimental mouse model of obesity can be generated by feeding either a high
fat diet (HFD) or very high fat diet (VHFD) for specified period of time; diet
based on investigator preference for study needs. Differences in body weight can
be seen as soon as 2 weeks after the initiation of feeding HFD. After 4 weeks on
HFD, many mice begin exhibiting hyperglycemia with the full obese phenotype
measureable after 16 weeks. Within 16-20 weeks mice may experience a 20-30%
increase in body weight, adipocyte hyperplasia, fat deposition in the mesentery,
increased fat mass, diabetes, and hypertension. The effect of the diet on
obesity development is directly related to the fat content of the diet and the
length of time the animal spends on the diet with variability in severity of
metabolic changes observed between individual animals. The Animal Care Core
works with the users in designing a study with appropriate feeding duration and
selection of diet with respect to percent and composition of fat in the diet.
DataData will be collected for this catalog item
Keywordsanimal model, diet-induced obesity, food intake, high-fat diet, insulin, insulin
action, mouse husbandry and transfer, obesity, type 2 diabetes
Tissuesadipose tissue



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