mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Catalog Item
Exercise capacity/Exercise Stress Test (metabolic response to exercise)
Common Name(s): Energy balance—food intake, energy expenditure, physical activity, Exercise capacity with gas exchange, Treadmill exercise training

CenterVanderbilt University School of Medicine
Center CoreMetabolic Regulation Core
Test No.V3013
Test PriceInquire for Pricing
DescriptionExercise is an integrated measure of fitness. Abnormal exercise capacity and
decreased activity are a hallmark of most severe cardiovascular and metabolic
diseases, and changes in exercise capacity are sensitive and early markers of
cardiac and metabolic dysfunction. Thus abnormalities can be revealed with
exercise that may not otherwise be manifested. Gas exchange techniques can be
used during treadmill exercise in the mouse to describe the metabolic cost of
exercise. Substrate fluxes and metabolism can be assessed isotopically during
exercise in chronically catheterized mice (Halseth et al. Am. J. Physiol. 1999).
Treadmill exercise can be used to quantify the capacity of a mouse for either
endurance or high intensity exercise. Peak exercise capacity and VO2 max will be
measured using a closed gas exchange treadmill. Acclimated mice will exercise
will at 10 m/min, 0° grade, increased to 14 m/min, 3 minutes later and then
increased by 4 m/min a every 3 min thereafter up to 46 m/min or until mouse is
exhausted. Exhaustion is defined as the mouse sitting on the shock pad and
unable to get off. Time to exhaustion and speed at exhaustion is recorded.
DataData will be collected for this catalog item
KeywordsActivity, endurance, exercise capacity, exercise stress test, exercise tolerance
Tissuesheart, skeletal muscle



Catalog Groups



Phenotype Assays



Experimental Factors
NameUnitsDescriptionAbbreviationMin ValueMax ValueCategoricalBatchOptions
Mouse Diet 
This is the food/chow mice were fed during the experiment.
 --TrueFalse
View



Protocols

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.