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Experiment

Investigation of systemic loss of bone mass following bone fracture in older (1
yo) mice- DEXA analysis with baseline and 3 timepoints post-fracture
Summary Data Summary
Investigator Christiansen, Blaine
Description We will use a total of 16 mice for these studies. Mice from each group will be
fractured, sham-injured, or uninjured controls (n=5-6 mice per group). At each
time point (4 days, 2, 4, and 6 weeks post-fracture), mice
will be individually housed for 24 hours in an isolated, enclosed chamber (16
inch square) designed to evaluate voluntary activity . At each time point (4
days, 2, 4, and 6 weeks post-fracture) mice will be anesthetized and imaged with
DEXA to determine whole-body bone mineral content, bone mineral density, and
body composition. The head and the right (injured) femur will be excluded.
Status Completed
Public Release 12/10/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals16
Experimental Conditions3
Catalog Items1
Curation Info (# flags)1
Phenotype Assays7
Phenotype Measurements448
Histology Images0
Publications0
Phenotypes9


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
16
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Surgical Procedure

 anesthesia control
The anesthesia control animals.
 femur fracture
The femur is experimentally fractured.
 Sham
Control Sham Procedure

Experimental Factor: Time Since Surgery (day)

 Time Since Surgery (
The time, in days, since the surgery was performed.



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0000063decreased bone mineral density
reduction in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0003961decreased lean body mass
reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0005459decreased percent body fat/body weight
less fat| relative to controls| expressed as a percentage of total body weight [MGI:cwg]
MMPC Search Results
MP:0010025decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0013616decreased volumetric bone mineral density
reduction in the mineral mass per unit volume of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3)| with results generated from Quantitative computed tomography (QCT) and other tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0013618decreased areal bone mineral density
reduction of the mineral mass per unit area of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2)| with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0014143decreased body fat mass
decreased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results
MP:0020010decreased bone mineral density of femur
reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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