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Experiment

Circulating hormone and metabolite measurments in conditional Rai1 KO mice
Summary Data Summary
Investigator Luo, Liqun
Description Study the mouse model of Smith-Magenis syndrome

Applicable research area(s): Neurobiology, Metabolism
Status Completed
Public Release 4/26/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagExperiment Description
Data Analysis
TypeCount
Animals24
Experimental Conditions5
Catalog Items9
Curation Info (# flags)1
Phenotype Assays9
Phenotype Measurements216
Histology Images0
Publications0
Phenotypes7


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
8
0
0
Sim1cre;Rai1CKO
8
0
0
SF1cre;Rai1CKO
8
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001552increased circulating triglyceride level
greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue| commonly circulate in the blood in the form of lipoproteins| and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver [MGI:csmith]
MMPC Search Results
MP:0001556increased circulating HDL cholesterol level
higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion [MGI:csmith]
MMPC Search Results
MP:0001745increased circulating corticosterone level
greater than the normal amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion [ISBN:0-683-40008-8| MGI:csmith| PMID:10357937]
MMPC Search Results
MP:0005178increased circulating cholesterol level
greater than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids| including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues [MGI:csmith]
MMPC Search Results
MP:0005669increased circulating leptin level
greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance [MESH:D06.472.699.042.500]
MMPC Search Results
MP:0011549increased urine corticosterone level
an increased amount of corticosterone in the urine compared to the normal state [MGI:anna]
MMPC Search Results
MP:0011613decreased circulating ghrelin level
less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland [MGI:anna]
MMPC Search Results

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