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Experiment

Circulating lipid levels of B6 mice treated with niclosamide, cholestyramine,
and metformin
Summary Data Summary
Investigator Shengkan, Jin
Description We had the C57BL6/J mice randomized into 5 groups. These mice were all fed on
high-fat diet. Group 1 is controls without any treatment. Group 2 is niclosamide
treatment group with oral treatment of niclosamide mixed into diet 2000ppm.
Group 3 in metformin treatment group with oral treatment of metformin in water
to achieve dosage of 75 mg/kg/d. Group 4 is synergistic treatment group with
both niclosamide treatment group with oral treatment of niclosamide mixed into
diet 2000ppm plus 20000ppm cholestyramine mixed into diet. Group 5 is
synergistic treatment group with both niclosamide treatment group with oral
treatment of niclosamide mixed into diet 2000ppm plus 20000ppm cholestyramine
mixed into diet and metformin treatment. Blood samples were collected at age of
36 weeks after 5 hour fast. Each sample contains ~50 micro liters of plasma.

Applicable research area(s): Diabetes, Metabolism, Endocrine deficiency
Status Completed
Public Release 3/21/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals45
Experimental Conditions8
Catalog Items5
Curation Info (# flags)1
Phenotype Assays5
Phenotype Measurements225
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
45
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Metformin
Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target...
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D09032705G
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein
 Research Diets - D16012604
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D16012605
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein supplemented with 2000 ppm niclosamide ethanolamine (NEN) and 2% cholestyramine (COL)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)



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