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Strain
C57BL/6J

Summary Data Summary
Official Name C57BL/6J
Common Name C57BL/6J
Description C57BL/6J is the most widely used inbred strain and the first
to have its genome sequenced. Although this strain is
refractory to many tumors, it is a permissive background for
maximal expression of most mutations. C57BL/6J mice are
resistant to audiogenic seizures, have a relatively low bone
density, and develop age related hearing loss. They are also
susceptible to diet-induced obesity, type 2 diabetes, and
atherosclerosis. Macrophages from this strain are resistant
to the effects of anthrax lethal toxin.
TypeCount
Child Strains 2
Experiments 207
Publications 2
External References 1


OrderInvestigatorExperiment StatusMeasurements
2219122191Kanakadurga Singer
2016-08-15 Singer - Simin 32 Mice 3 Day CLAMS Run
Completed13568
2219122191Kanakadurga Singer
2016-08-15 Singer - Simin 32 Mice NMR
Completed384
2561125611Hannah Hafner
2018-04-30 Gregg - Hannah 8 mice NMR
Completed32
2629526295Alison Affinati
2019-10-15 Myers-Allison Cohort 3 17 mice Insulin Clamp
Completed714
2629526295Alison Affinati
2019-10-15 Myers-Allison Cohort 3 17 mice Insulin Clamp-Tissues
Completed34
3031930319Alison Affinati
2019-11-11 Myers-Alison Cohort 4-11 mice Insulin Clamp
Completed462
3031930319Alison Affinati
2019-11-11 Myers-Alison Cohort 4-11 mice Insulin Clamp-tissues
Completed22
3033830338Susan Allen
2019-12-16 Carol Elias 32 Mice NMR
Completed384
3033830338Susan Allen
2019-12-19 Carol Elias 32 Mice 3 Day CLAMS Run with Injections and T3 Water
Completed13824
3090530905David Olson
2021-10-10 Olson-Ian CLAMS 12 mice 5 days
Completed42720
21992199Man Li
3/7/11
In Progress9
21732173Lianfu Wang
4/25/11
In Progress0
202202Alyssa Hasty
Body Composition Order #202 4/9/04
Completed27
2189921899Miklos Peterfy
Circulating adiponectin levels in young and old B6 mice
In Progress76
2561225612Jin Shengkan
Circulating albumin, ALT, and AST levels in B6 mice treated with niclosamide and CCL4
Completed120
3035830358Jin Shengkan
Circulating ALT, and AST levels in B6 mice treated with derivatives of niclosamide and CCL4
Completed104
2210522105Karen Ryan
Circulating corticosterone and IGF-1 levels in B6 mice treated with FGF-21
Completed72
2621626216William Murphy
Circulating corticosterone levels in B6 mice injected with MCMV and treated with rat IgG, anti-NK1.1, anti-ASGM1
Completed15
2624626246William Murphy
Circulating corticosterone levels in B6 mice treated with IL-2
Completed23
2187521875Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma
Completed105
2209322093Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma and treated with flavopiradol
Completed170
2209322093Dominik Haudenschild
Circulating cytokine levels in B6 mice treated with LPS and JQ1
Completed420
2210822108Jin Shengkan
Circulating cytokine levels in B6 mice treated with NEN, metformin, and cholestyramine
Completed351
2201822018Karen Ryan
Circulating FFA and glycerol levels in B6 mice treated with FGF-21
Completed72
2573825738Allison Xu
Circulating FFA levels in B6 mice treated with ethanol and anti-Agrp RNAi
Completed44
2216922169Jon Ramsey
Circulating FGF-21 levels in B6 mice fed ketogenic diet
Completed30
2587925879Amparo Villablanca
Circulating glucose, insulin, and estradiol levels in Ldlr KO mice fed high fat diet
Completed36
2593525935Amparo Villablanca
Circulating glucose, insulin, and lipid levels in Ldlr KO mice fed high fat diet
Completed72
56795679Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice
Completed480
1091110911Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice pt2
In Progress156
3081130811Isha Jain
Circulating hormone levels in B6 mice exposed to hypoxic conditions
Completed180
77077707sanjeev kumar
Circulating insulin and leptin levels in B6 mice fed high fat diet treated with ShK-186
Completed66
25152515sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186
Completed32
25612561sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186 pt2
Completed40
2620426204Sunhye Lee
Circulating insulin levels following an OGTT in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed80
2560425604Saptarsi Haldar
Circulating insulin levels following glucose gavage in B6 mice
Completed24
3069330693Payam Vahmani
Circulating insulin levels in B6 mice fed high fat diet with different animal fat composition
Completed72
2237822378Jin Shengkan
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide
Completed17
2242422424Jin Shengkan
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide (part 2)
Completed36
2247222472Shengkan Jin
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide (part 3)
Completed36
2204322043Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide
Completed16
2211622116Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide ethanolamine
Completed20
2199421994Andreas Baumler
Circulating leptin levels in B6 mice fed high fat diet
Completed29
2563825638William Murphy
Circulating leptin levels in Lep KO mice treated with leptin
Completed15
2207022070Amparo Villablanca
Circulating lipid levels in Atf3 KO mice fed high fat diet
Completed144
2212522125Jin Shengkan
Circulating lipid levels of B6 mice treated with niclosamide, cholestyramine, and metformin
Completed225
3066730667Jon Ramsey
Circulating lipid, glucose and insulin, inflammatory marker, IGF1 and FGF21 levels in B6 mice fed ketogenic diet
Completed420
2586125861Manuel Navedo
Circulating lipid, glucose, insulin and HbA1c levels in AC5 KO mice fed high fat diet
Completed168
2586125861Manuel Navedo
Circulating lipid, glucose, insulin and HbA1c levels in AC5 KO mice treated with streptozotocin
Completed161
2180721807Jon Ramsey
Circulating metabolic and inflammatory marker levels in B6 mice fed ketogenic diet
Completed378
2204722047Karen Ryan
Circulating TC and TG levels in B6 mice fed low protein diet
Completed154
2176021760John Rutledge
Cognitive assessment of c57BL/6 and LDLr -/- mice on a western diet
Completed3240
3046230462Amparo Villablanca
Cognitive effects of high glycemic index diet + sHE inhibitor trans-AUCB or HGI-curcumin diet on mice.
Completed35
2622626226Amparo Villablanca
Cognitive effects of high glycemic index diet in male and female mice.
Completed28
3046130461Amparo Villablanca
Cognitive effects of western diet in female c57BL/6J and LDLR -/- mice.
Completed20
2193521935Michael Jurczak
Deuterium water CLAMS
Completed320
2194721947Wajahat Mehal
Digoxin CLAMS
Completed165
17471747Mary Zutter
Echocardiography Order #1747 9/18/09
In Progress140
17481748Jeff Rottman
Echocardiography Order #1748 9/18/09
In Progress510
17651765Ji Ma
Echocardiography Order #1765 9/30/09
In Progress70
17671767Ming-Zhi Zhang
Echocardiography Order #1767 10/2/09
In Progress80
939939David Bader
Echocardiography Order #939 8/1/05
Completed153
2225522255Maria Marco
Effect effects of dietary starch and probiotics on plasma LBP in DIO mouse model
Completed40
2600326003Benjamin Renquist
Effect of ABAT ASO knock down on substrate oxidation and energy expenditure in DIO mice.
Completed1116
2600726007Trina Knotts
Effect of antibiotics on energy expenditure in A/J and C57BL/6J mice fed a low- or high-fat diet.
Completed1917
2250422504Trina Knotts
Effect of antibiotics on energy expenditure in Ob/Ob and C57BL/6J (WT) mice
Completed1127
3038530385Jonah Sinick
Effect of Dinitrophenol (DNP) and mitochondrial uncouplers on Energy expenditure.
Completed1984
2622626226Amparo Villablanca
Effect of HGI diet on open field performance in male and female mice
Completed112
3046230462Amparo Villablanca
Effect of high glycemic index diet + sHE inhibitor trans-AUCB or HGI-curcumin on open field performance in C57BL/6J mice
Completed140
3064530645Helen Raybould
Effect of Lacto-N-tetraose (LNT) on cognition with control or high fat diet.
Completed80
3064530645Helen Raybould
Effect of Lacto-N-tetraose, (LNT) on open field performance with control or high fat diet
Completed160
2237622376Helen Raybould
Effect of Monobutyrin on HFD induced metabolic endotoxemia
Completed24
2237622376Helen Raybould
Effect of Monobutyrin on Intestinal Permeability
Completed92
2627726277Jin Shengkan
Effect of Niclosamide Derivatives on Energy Expenditure
Completed930
3099330993John Yoon
Effect of UCP1 overexpression on energy expenditure in males at room temperature (22C) and under cold challenge
Completed864
3046130461Amparo Villablanca
Effect of western diet on open field performance in C57BL/6J and LDLR -/- mice
Completed80
3080430804Michael Goodson
Effect of Whey protein and whey phospholipid on cognition in weanling mice with a HFD
Completed81
3080430804Michael Goodson
Effect of Whey protein and whey phospholipid on cognition with a HFD
Completed90
2250522505Helen Raybould
Effects of Inulin on high fat diet mediated obesity and gut permeability
Completed94
2250522505Helen Raybould
Effects of Inulin on high fat diet mediated obesity and metabolic endotoxemia
Completed48
25202520Chi Bun Chan
Energy Balance/SABLE Order #2520 4/16/12
Completed351
1320513205Danny Winder
Energy Balance/SABLE Order#13205 7/22/14
Completed372
1204712047David Harrison
Energy Balance/SABLE/GTT Order #12047 3/13/14
Completed1764
1201512015Saptarsi Haldar
Energy Balance/SABLE/Oxymax Max Test Order #12015 2/4/14
Completed384
1859018590Stephen Wheatcroft
Energy Expenditure - Promethion
In Progress192
15001500Richard O'Brien
Energy Expenditure Order #1500 4/16/08
Completed0
17221722Muhammad Abdul-Ghani
Energy Expenditure Order #1722 7/13/09
In Progress680
16141614Wayne Jiang
Experiment for Order #1614
Completed32
17131713ARTHUR SIMEN
Experiment for Order #1713
Completed140
17601760Miguel Ortiz
Experiment for Order #1760
In Progress136
18101810Laurie Minze
Experiment for Order #1810
Completed186
18151815Laurie Minze
Experiment for Order #1815
Completed54
16611661Domenico Accili
Foxo1+/-;Notch1+/- mouse studies (RC and HFD)
Completed442
2182021820Leslie Crofford
Glucose Tolerance Test #21820 10/19/15
Completed3840
56755675Sean Davies
Gut microbiome analysis- effect of colonization with E.coli strain overexpressing enzyme to overproduce anorexigenic lipids
Completed78
1539215392Trina Knotts
Gut microbiome analysis in wild-type C57BL/6J chow-fed mice: Effect of gut location(biogeography) and sequencing method on microbiota diversity
Completed60
1849618496Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in Chow and HFD-fed mice
Completed24
1317613176Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in chow-fed mice
Completed24
2248822488Eva Feldman
HbA1c levels in B6 mice treated with streptozotocin
Completed14
2204422044Xin Jie Chen
Hormone Measurements #22044 9/19/16
Completed64
944944David Wasserman
Hyperglycemic Clamp Order #944 10/18/05
Completed1050
982982David Wasserman
Hyperglycemic Clamp Order #982 10/18/05
Completed1050
836836Aamir Zuberi
Hyperglycemic Insulinemic Clamp Order #836 1/31/05
Completed1439
2626David Wasserman
HYPERINSULINEMIC CLAMP - HYPERINSULINEMIC CLAMP - V3005 PXN1218, V3005A PXN1218
Completed1591
1316713167April Stull
Hyperinsulinemic Clamp Order #13167 November 2014
Completed6066
12011201Thomas W Gettys
Hyperinsulinemic Clamp Order #1207 8/16/06
Completed2503
14701470Calvin Kuo
Hyperinsulinemic Clamp Order #1470 2/26/08
Completed3816
18481848Thomas W Gettys
Hyperinsulinemic Clamp Order #1848 2/11/10
Completed816
1857618576Matthew Robinson
Hyperinsulinemic clamp Order #18576 ,January 2016
Completed5016
20902090Thomas W Gettys
Hyperinsulinemic Clamp Order #2090 1/4/11
Completed4866
22592259Carol MacKintosh
Hyperinsulinemic Clamp Order #2259 6/20/11
In Progress4831
23452345Suzanne Jackowski
Hyperinsulinemic Clamp Order #2345 9/29/11
Completed4794
24132413Jianping Ye
Hyperinsulinemic Clamp Order #2413 12/21/11
Completed5134
24362436Joanne Tobacman
Hyperinsulinemic Clamp Order #2436 1/23/12
Completed4661
77047704Dimitris Skokos
Hyperinsulinemic Clamp Order #7704 2/7/13
Completed4923
2828David Wasserman
Hyperinsulinemic clamps - V3005 PXN1220
Completed197
1859018590Stephen Wheatcroft
Hyperinsulinemic Euglycemic clamp order #18590, November 2015
Completed5145
1970419704Vance Albaugh
Hyperinsulinemic Euglycemic clamp order #19704 September 2015
Completed3962
36473647Nathan Rehmer
Hyperinsulinemic Euglycemic Clamp Order #3647 11/2/12
In Progress6524
21762176Tae-Hwa Chun
Hyperinsulinemic Euglycemic Clamp Order#2176 2/8/11
Completed7782
16821682Marco Giorgio
Hyperinsulinemic-euglycemic clamp in p66shc-/- mice on a regular diet
Completed247
2177421774Daniel Okin
Hyperinsulinemic-euglycemic clamp on LPS injected mice
Completed143
14601460Yuxiang Sun
Hyperinsulinemic-Euglycemic Clamp Order #1460 1/10/08
Completed711
2211022110Carl Johnson
Impact of High Fat Diet Choice on Energy Balance
Completed1248
547547Grant Mitchell
In vivo metabolism - In vivo metabolism - Y4001 PXN1758, Y4005 PXN1758
Completed219
546546Suresh Mathews
In vivo metabolism - Y4001 PXN1757
Completed214
2201422014John Rutledge
Influence of control or western diet on brain metabolites in C57bl/6 or LDLr-/- mice
Completed16
1644616446Natalie Torok
IPGTT insulin levels in C57 mice injected with shNOX4 adenovirus
Completed44
2195521955John Wysolmerski
Lactating mice CLAMS
Completed150
2195521955John Wysolmerski
Lactating mice GTT
Completed291
25202520Chi Bun Chan
Leptin Injection/Food Intake/Mouse Weight Monitoring Order #2520 4/16/12
Completed192
25452545Sue Bodine
Lipid droplet and mitochondrial analysis in aged MURF/1 KO Mice
Completed2
2587525875Guangping Gao
Liver GSH levels in B6 mice treated with miR375 and acetominophen
Completed60
2610626106Guangping Gao
Liver GSH levels in B6 mice treated with miR375 and acetominophen Part 2
Completed124
3066730667Jon Ramsey
Liver lipid levels in B6 mice fed ketogenic diet
Completed48
56785678Giles Duffield
Liver lipid levels in Id2 KO mice
Completed128
1091210912Giles Duffield
Liver lipid levels in Id2 KO mice pt2
Completed32
2612526125Jin Shengkan
Liver lipid levels in Lepr KO mice treated with derivatives of niclosamide
Completed98
2212622126Jin Shengkan
Liver lipid levels of B6 mice treated with niclosamide
Completed36
2621226212Sunhye Lee
Liver lipids in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed64
2624326243Sunhye Lee
Liver lipids in B6 mice fed high fat diet and treated with human milk oligosaccharides Part 2
Completed16
2204622046Karen Ryan
Liver TC and TG levels in B6 mice treated with FGF21
Completed152
2197621976Karen Ryan
Liver TG and TC levels in FGF-21 treated C57 mice
Completed72
2609126091Sunhye Lee
Liver TG in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed36
2250422504Trina Knotts
Liver TG levels in Lep KO mice treated with anitbiotics
Completed98
2183521835Karen Ryan
Liver TG measurements in B6 mice fed protein restricted diets
Completed128
2176221762Jin Shengkan
Liver TG measurements in B6 mice treated with metformin and niclosamide
Completed96
2181121811Holly Ingraham
Liver TG measurements in liver specific Nr5a2 KO mice fed high fat diet
Completed20
2188421884Gerald I. Shulman
Longer vs shorter fast clamp
Completed117
1858718587Jon Ramsey
Measurement of energy expenditure, RER and body composition in 12 month old mice placed on one of 3 diets(control (AIN93G), ketogenic (90% fat, 10% protein, 0.7% carbohydrate), or low carb (70%fat, 20% protein, 10% carbohydrate)) for 1 month.
Completed620
2072620726Jon Ramsey
Measurement of energy expenditure, RER and body composition in 28 month old mice on one of 3 diets (control (AIN93G), ketogenic, or low carbohydrate diets for 1 year.
Completed391
1643716437Wencheng Li
Metabolic measurements in B6 mice fed high fat diet
Completed45
2186421864Jin Shengkan
Metabolic measurements in B6 mice treated with metformin and niclosamide
Completed96
2183521835Karen Ryan
Metabolic measurements in C57 mice on protein restricted diets
Completed128
2186121861Karen Ryan
Metabolic measurements in C57 mice treated with FGF21
Completed76
2073020730Jin Shengkan
Metabolic measurements in HFD fed B6 mice treated with niclosamide and metformin
Completed160
2206722067Jon Ramsey
Metabolic measurements in p65Schc -/- mice
Completed868
1969619696Kei Sakamoto
Metformin clamp Order #19696, April 2015
Completed8462
1848218482Carlos Fernandez-Hernando
miR33 KO clamp
Completed234
1319513195Owen McGuinness
MMPC Energy Balance Study Order #13195 7/17/14
Completed525
1642216422Jon Ramsey
Muscle TG levels in Shc KO mice
Completed24
16211621Romina Fiorotto
Notch2 is required for proper IHBD development and morphogenesis.
Completed111
2190821908Natalie Torok
NOX4 LKO clamps
Completed234
25772577Jonathan Schoenecker
Oxymax Order #2577 6/28/12
Completed66
36293629David Wasserman
Oxymax Part 1 Order #3629 10/17/12
Completed310
36293629David Wasserman
Oxymax Part 2 Order #3629 10/17/12
Completed296
36173617Carl Johnson
Oxymax/Black Box (Altered Light Dark Period) Order #3617 10/1/12
Completed88
77117711John Stafford
Oxymax/Treadmill Max Test Order #7711 2/19/13
Completed104
19971997Saptarsi Haldar
Oxymax/Treadmill Order #1997 8/13/10
Completed2935
1326413264John Rutledge
Plasma metabolomics in non-fasted control and Western diet fed WT and LDLRKO mice
Completed40
2197621976Karen Ryan
Plasma TG and TC levels in FGF-21 treated C57 mice
Completed72
78407840Owen McGuinness
Ppar/Sable/GTT Order #7840 6/10/13
Completed3369
2181421814Owen McGuinness
Sable Energy Balance # 21814 10/1/15
Completed224
2182021820Leslie Crofford
Sable Energy Balance # 21820 10/19/15
Completed1078
2206922069Richard Simerly
Sable Energy Balance # 22069 12/5/16
Completed208
1857618576Matthew Robinson
Sable Energy Balance #18576 1/4/16
Completed560
2175021750David Wasserman
Sable Energy Balance #21750 4/13/15
Completed192
2175221752Italo Biaggioni
Sable Energy Balance #21752 1/18/16
Completed156
2180921809Owen McGuinness
Sable Energy Balance #21809 2/18/15
Completed576
2181421814Owen McGuinness
Sable Energy Balance #21814 8/28/15
Completed192
2202322023David Wasserman
Sable Energy Balance #22023 6/16/16
Completed1820
2203922039Richard Simerly
Sable Energy Balance #22039 9/8/16
Completed156
2204422044Xin Jie Chen
Sable Energy Balance #22044 9/19/16
Completed224
2206922069Richard Simerly
Sable Energy Balance #22069 10/14/16
Completed52
2207622076Anna Hemnes
Sable Energy Balance #22076 9/26/16
Completed532
2208522085John Stafford
Sable Energy Balance #22085 10/21/16
Completed336
2209722097David Wasserman
Sable Energy Balance #22097 11/14/16
Completed392
2212322123Richard Simerly
Sable Energy Balance #22123 12/19/16
Completed392
2218022180John Stafford
Sable Energy Balance #22180 3/6/17
Completed224
2221622216Anna Hemnes
Sable Energy Balance #22216 3/13/17
Completed210
2222322223Alyssa Hasty
Sable Energy Balance #22223 3/27/17
Completed224
2223322233Sophia Yu
Sable Energy Balance #22233 4/3/17
Completed224
2238222382Daniel Lark
Sable Energy Balance #22382 7/19/17
Completed448
2239822398Steffen Daub
Sable Energy Balance #22398 10/9/17
Completed224
2453224532Jacob Brown
Sable Energy Balance #24532 3/16/18
Completed224
2560125601Sarah Davis
Sable Energy Balance #25601 1/29/18
Completed448
1848418484David Wasserman
Sable Energy Balance 2/23/15 #18484
Completed288
1849518495David Jacobson
Sable Energy Balance 3/2/15 #18495
Completed192
1309713097Weiqin Chen
Sable Energy Balance 8/25/14 #13097
Completed156
77057705David Wasserman
SABLE Order #7705 2/7/13
Completed154
77167716John Stafford
SABLE Order #7716 2/21/13
Completed132
77527752David Wasserman
Sable Order #7752 3/28/13
Completed142
2072720727Helen Raybould
Sex differences in energy expenditure, meal patterns, and body composition in response to short term high fat diet (4 weeks)
Completed1550
17581758Ming-Zhi Zhang
Tail Cuff Blood Pressure Order #1758 9/24/09
In Progress100
17881788Richard Breyer
Tail Cuff Blood Pressure Order #1788 11/11/09
Completed60
36503650Patty Lee
Ucp2 KO hypoxia CLAMS
Completed54
2237922379David Mills
Understanding the effects of prebiotic 2-Fucosyl-Lactose on gut permeability and plasma LBP
Completed216




PublicationAltmetricsSubmitted ByPubMed IDStatus
Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice.
McGavigan AK, Henseler ZM, Garibay D, Butler SD, Jayasinghe S, Ley RE, Davisson RL, Cummings BP
Disease models & mechanisms, 2017 (10), 235 - 243
Submitted Externally
28093508
Published
Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability and microbial dysbiosis in high-fat fed mice.
Hamilton MK, Ronveaux CC, Rust BM, Newman JW, Hawley M, Barile D, Mills DA, Raybould HE
American journal of physiology. Gastrointestinal and liver physiology, 2017, ajpgi.0042
Submitted Externally
28280143
Published


External References
NameLink to Reference
Mouse Phenome Database: StrainsClick to view

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