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Strain
C57BL/6J

Summary Data Summary
Official Name C57BL/6J
Common Name C57BL/6J
Description C57BL/6J is the most widely used inbred strain and the first
to have its genome sequenced. Although this strain is
refractory to many tumors, it is a permissive background for
maximal expression of most mutations. C57BL/6J mice are
resistant to audiogenic seizures, have a relatively low bone
density, and develop age related hearing loss. They are also
susceptible to diet-induced obesity, type 2 diabetes, and
atherosclerosis. Macrophages from this strain are resistant
to the effects of anthrax lethal toxin.
TypeCount
Child Strains 2
Experiments 207
Publications 2
External References 1


OrderInvestigatorExperiment StatusMeasurements
22191Kanakadurga Singer
2016-08-15 Singer - Simin 32 Mice 3 Day CLAMS Run
Completed13568
22191Kanakadurga Singer
2016-08-15 Singer - Simin 32 Mice NMR
Completed384
25611Hannah Hafner
2018-04-30 Gregg - Hannah 8 mice NMR
Completed32
26295Alison Affinati
2019-10-15 Myers-Allison Cohort 3 17 mice Insulin Clamp
Completed714
26295Alison Affinati
2019-10-15 Myers-Allison Cohort 3 17 mice Insulin Clamp-Tissues
Completed34
30319Alison Affinati
2019-11-11 Myers-Alison Cohort 4-11 mice Insulin Clamp
Completed462
30319Alison Affinati
2019-11-11 Myers-Alison Cohort 4-11 mice Insulin Clamp-tissues
Completed22
30338Susan Allen
2019-12-16 Carol Elias 32 Mice NMR
Completed384
30338Susan Allen
2019-12-19 Carol Elias 32 Mice 3 Day CLAMS Run with Injections and T3 Water
Completed13824
30905David Olson
2021-10-10 Olson-Ian CLAMS 12 mice 5 days
Completed42720
2199Man Li
3/7/11
In Progress9
2173Lianfu Wang
4/25/11
In Progress0
202Alyssa Hasty
Body Composition Order #202 4/9/04
Completed27
21899Miklos Peterfy
Circulating adiponectin levels in young and old B6 mice
In Progress76
25612Jin Shengkan
Circulating albumin, ALT, and AST levels in B6 mice treated with niclosamide and CCL4
Completed120
30358Jin Shengkan
Circulating ALT, and AST levels in B6 mice treated with derivatives of niclosamide and CCL4
Completed104
22105Karen Ryan
Circulating corticosterone and IGF-1 levels in B6 mice treated with FGF-21
Completed72
26216William Murphy
Circulating corticosterone levels in B6 mice injected with MCMV and treated with rat IgG, anti-NK1.1, anti-ASGM1
Completed15
26246William Murphy
Circulating corticosterone levels in B6 mice treated with IL-2
Completed23
21875Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma
Completed105
22093Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma and treated with flavopiradol
Completed170
22093Dominik Haudenschild
Circulating cytokine levels in B6 mice treated with LPS and JQ1
Completed420
22108Jin Shengkan
Circulating cytokine levels in B6 mice treated with NEN, metformin, and cholestyramine
Completed351
22018Karen Ryan
Circulating FFA and glycerol levels in B6 mice treated with FGF-21
Completed72
25738Allison Xu
Circulating FFA levels in B6 mice treated with ethanol and anti-Agrp RNAi
Completed44
22169Jon Ramsey
Circulating FGF-21 levels in B6 mice fed ketogenic diet
Completed30
25879Amparo Villablanca
Circulating glucose, insulin, and estradiol levels in Ldlr KO mice fed high fat diet
Completed36
25935Amparo Villablanca
Circulating glucose, insulin, and lipid levels in Ldlr KO mice fed high fat diet
Completed72
5679Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice
Completed480
10911Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice pt2
In Progress156
30811Isha Jain
Circulating hormone levels in B6 mice exposed to hypoxic conditions
Completed180
7707sanjeev kumar
Circulating insulin and leptin levels in B6 mice fed high fat diet treated with ShK-186
Completed66
2515sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186
Completed32
2561sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186 pt2
Completed40
26204Sunhye Lee
Circulating insulin levels following an OGTT in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed80
25604Saptarsi Haldar
Circulating insulin levels following glucose gavage in B6 mice
Completed24
30693Payam Vahmani
Circulating insulin levels in B6 mice fed high fat diet with different animal fat composition
Completed72
22378Jin Shengkan
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide
Completed17
22424Jin Shengkan
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide (part 2)
Completed36
22472Shengkan Jin
Circulating insulin levels in B6 mice gavaged with derivatives of niclosamide (part 3)
Completed36
22043Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide
Completed16
22116Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide ethanolamine
Completed20
21994Andreas Baumler
Circulating leptin levels in B6 mice fed high fat diet
Completed29
25638William Murphy
Circulating leptin levels in Lep KO mice treated with leptin
Completed15
22070Amparo Villablanca
Circulating lipid levels in Atf3 KO mice fed high fat diet
Completed144
22125Jin Shengkan
Circulating lipid levels of B6 mice treated with niclosamide, cholestyramine, and metformin
Completed225
30667Jon Ramsey
Circulating lipid, glucose and insulin, inflammatory marker, IGF1 and FGF21 levels in B6 mice fed ketogenic diet
Completed420
25861Manuel Navedo
Circulating lipid, glucose, insulin and HbA1c levels in AC5 KO mice fed high fat diet
Completed168
25861Manuel Navedo
Circulating lipid, glucose, insulin and HbA1c levels in AC5 KO mice treated with streptozotocin
Completed161
21807Jon Ramsey
Circulating metabolic and inflammatory marker levels in B6 mice fed ketogenic diet
Completed378
22047Karen Ryan
Circulating TC and TG levels in B6 mice fed low protein diet
Completed154
21760John Rutledge
Cognitive assessment of c57BL/6 and LDLr -/- mice on a western diet
Completed3240
30462Amparo Villablanca
Cognitive effects of high glycemic index diet + sHE inhibitor trans-AUCB or HGI-curcumin diet on mice.
Completed35
26226Amparo Villablanca
Cognitive effects of high glycemic index diet in male and female mice.
Completed28
30461Amparo Villablanca
Cognitive effects of western diet in female c57BL/6J and LDLR -/- mice.
Completed20
21935Michael Jurczak
Deuterium water CLAMS
Completed320
21947Wajahat Mehal
Digoxin CLAMS
Completed165
1747Mary Zutter
Echocardiography Order #1747 9/18/09
In Progress140
1748Jeff Rottman
Echocardiography Order #1748 9/18/09
In Progress510
1765Ji Ma
Echocardiography Order #1765 9/30/09
In Progress70
1767Ming-Zhi Zhang
Echocardiography Order #1767 10/2/09
In Progress80
939David Bader
Echocardiography Order #939 8/1/05
Completed153
22255Maria Marco
Effect effects of dietary starch and probiotics on plasma LBP in DIO mouse model
Completed40
26003Benjamin Renquist
Effect of ABAT ASO knock down on substrate oxidation and energy expenditure in DIO mice.
Completed1116
26007Trina Knotts
Effect of antibiotics on energy expenditure in A/J and C57BL/6J mice fed a low- or high-fat diet.
Completed1917
22504Trina Knotts
Effect of antibiotics on energy expenditure in Ob/Ob and C57BL/6J (WT) mice
Completed1127
30385Jonah Sinick
Effect of Dinitrophenol (DNP) and mitochondrial uncouplers on Energy expenditure.
Completed1984
26226Amparo Villablanca
Effect of HGI diet on open field performance in male and female mice
Completed112
30462Amparo Villablanca
Effect of high glycemic index diet + sHE inhibitor trans-AUCB or HGI-curcumin on open field performance in C57BL/6J mice
Completed140
30645Helen Raybould
Effect of Lacto-N-tetraose (LNT) on cognition with control or high fat diet.
Completed80
30645Helen Raybould
Effect of Lacto-N-tetraose, (LNT) on open field performance with control or high fat diet
Completed160
22376Helen Raybould
Effect of Monobutyrin on HFD induced metabolic endotoxemia
Completed24
22376Helen Raybould
Effect of Monobutyrin on Intestinal Permeability
Completed92
26277Jin Shengkan
Effect of Niclosamide Derivatives on Energy Expenditure
Completed930
30993John Yoon
Effect of UCP1 overexpression on energy expenditure in males at room temperature (22C) and under cold challenge
Completed864
30461Amparo Villablanca
Effect of western diet on open field performance in C57BL/6J and LDLR -/- mice
Completed80
30804Michael Goodson
Effect of Whey protein and whey phospholipid on cognition in weanling mice with a HFD
Completed81
30804Michael Goodson
Effect of Whey protein and whey phospholipid on cognition with a HFD
Completed90
22505Helen Raybould
Effects of Inulin on high fat diet mediated obesity and gut permeability
Completed94
22505Helen Raybould
Effects of Inulin on high fat diet mediated obesity and metabolic endotoxemia
Completed48
2520Chi Bun Chan
Energy Balance/SABLE Order #2520 4/16/12
Completed351
13205Danny Winder
Energy Balance/SABLE Order#13205 7/22/14
Completed372
12047David Harrison
Energy Balance/SABLE/GTT Order #12047 3/13/14
Completed1764
12015Saptarsi Haldar
Energy Balance/SABLE/Oxymax Max Test Order #12015 2/4/14
Completed384
18590Stephen Wheatcroft
Energy Expenditure - Promethion
In Progress192
1500Richard O'Brien
Energy Expenditure Order #1500 4/16/08
Completed0
1722Muhammad Abdul-Ghani
Energy Expenditure Order #1722 7/13/09
In Progress680
1614Wayne Jiang
Experiment for Order #1614
Completed32
1713ARTHUR SIMEN
Experiment for Order #1713
Completed140
1760Miguel Ortiz
Experiment for Order #1760
In Progress136
1810Laurie Minze
Experiment for Order #1810
Completed186
1815Laurie Minze
Experiment for Order #1815
Completed54
1661Domenico Accili
Foxo1+/-;Notch1+/- mouse studies (RC and HFD)
Completed442
21820Leslie Crofford
Glucose Tolerance Test #21820 10/19/15
Completed3840
5675Sean Davies
Gut microbiome analysis- effect of colonization with E.coli strain overexpressing enzyme to overproduce anorexigenic lipids
Completed78
15392Trina Knotts
Gut microbiome analysis in wild-type C57BL/6J chow-fed mice: Effect of gut location(biogeography) and sequencing method on microbiota diversity
Completed60
18496Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in Chow and HFD-fed mice
Completed24
13176Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in chow-fed mice
Completed24
22488Eva Feldman
HbA1c levels in B6 mice treated with streptozotocin
Completed14
22044Xin Jie Chen
Hormone Measurements #22044 9/19/16
Completed64
944David Wasserman
Hyperglycemic Clamp Order #944 10/18/05
Completed1050
982David Wasserman
Hyperglycemic Clamp Order #982 10/18/05
Completed1050
836Aamir Zuberi
Hyperglycemic Insulinemic Clamp Order #836 1/31/05
Completed1439
26David Wasserman
HYPERINSULINEMIC CLAMP - HYPERINSULINEMIC CLAMP - V3005 PXN1218, V3005A PXN1218
Completed1591
13167April Stull
Hyperinsulinemic Clamp Order #13167 November 2014
Completed6066
1201Thomas W Gettys
Hyperinsulinemic Clamp Order #1207 8/16/06
Completed2503
1470Calvin Kuo
Hyperinsulinemic Clamp Order #1470 2/26/08
Completed3816
1848Thomas W Gettys
Hyperinsulinemic Clamp Order #1848 2/11/10
Completed816
18576Matthew Robinson
Hyperinsulinemic clamp Order #18576 ,January 2016
Completed5016
2090Thomas W Gettys
Hyperinsulinemic Clamp Order #2090 1/4/11
Completed4866
2259Carol MacKintosh
Hyperinsulinemic Clamp Order #2259 6/20/11
In Progress4831
2345Suzanne Jackowski
Hyperinsulinemic Clamp Order #2345 9/29/11
Completed4794
2413Jianping Ye
Hyperinsulinemic Clamp Order #2413 12/21/11
Completed5134
2436Joanne Tobacman
Hyperinsulinemic Clamp Order #2436 1/23/12
Completed4661
7704Dimitris Skokos
Hyperinsulinemic Clamp Order #7704 2/7/13
Completed4923
28David Wasserman
Hyperinsulinemic clamps - V3005 PXN1220
Completed197
18590Stephen Wheatcroft
Hyperinsulinemic Euglycemic clamp order #18590, November 2015
Completed5145
19704Vance Albaugh
Hyperinsulinemic Euglycemic clamp order #19704 September 2015
Completed3962
3647Nathan Rehmer
Hyperinsulinemic Euglycemic Clamp Order #3647 11/2/12
In Progress6524
2176Tae-Hwa Chun
Hyperinsulinemic Euglycemic Clamp Order#2176 2/8/11
Completed7782
1682Marco Giorgio
Hyperinsulinemic-euglycemic clamp in p66shc-/- mice on a regular diet
Completed247
21774Daniel Okin
Hyperinsulinemic-euglycemic clamp on LPS injected mice
Completed143
1460Yuxiang Sun
Hyperinsulinemic-Euglycemic Clamp Order #1460 1/10/08
Completed711
22110Carl Johnson
Impact of High Fat Diet Choice on Energy Balance
Completed1248
547Grant Mitchell
In vivo metabolism - In vivo metabolism - Y4001 PXN1758, Y4005 PXN1758
Completed219
546Suresh Mathews
In vivo metabolism - Y4001 PXN1757
Completed214
22014John Rutledge
Influence of control or western diet on brain metabolites in C57bl/6 or LDLr-/- mice
Completed16
16446Natalie Torok
IPGTT insulin levels in C57 mice injected with shNOX4 adenovirus
Completed44
21955John Wysolmerski
Lactating mice CLAMS
Completed150
21955John Wysolmerski
Lactating mice GTT
Completed291
2520Chi Bun Chan
Leptin Injection/Food Intake/Mouse Weight Monitoring Order #2520 4/16/12
Completed192
2545Sue Bodine
Lipid droplet and mitochondrial analysis in aged MURF/1 KO Mice
Completed2
25875Guangping Gao
Liver GSH levels in B6 mice treated with miR375 and acetominophen
Completed60
26106Guangping Gao
Liver GSH levels in B6 mice treated with miR375 and acetominophen Part 2
Completed124
30667Jon Ramsey
Liver lipid levels in B6 mice fed ketogenic diet
Completed48
5678Giles Duffield
Liver lipid levels in Id2 KO mice
Completed128
10912Giles Duffield
Liver lipid levels in Id2 KO mice pt2
Completed32
26125Jin Shengkan
Liver lipid levels in Lepr KO mice treated with derivatives of niclosamide
Completed98
22126Jin Shengkan
Liver lipid levels of B6 mice treated with niclosamide
Completed36
26212Sunhye Lee
Liver lipids in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed64
26243Sunhye Lee
Liver lipids in B6 mice fed high fat diet and treated with human milk oligosaccharides Part 2
Completed16
22046Karen Ryan
Liver TC and TG levels in B6 mice treated with FGF21
Completed152
21976Karen Ryan
Liver TG and TC levels in FGF-21 treated C57 mice
Completed72
26091Sunhye Lee
Liver TG in B6 mice fed high fat diet and treated with human milk oligosaccharides
Completed36
22504Trina Knotts
Liver TG levels in Lep KO mice treated with anitbiotics
Completed98
21835Karen Ryan
Liver TG measurements in B6 mice fed protein restricted diets
Completed128
21762Jin Shengkan
Liver TG measurements in B6 mice treated with metformin and niclosamide
Completed96
21811Holly Ingraham
Liver TG measurements in liver specific Nr5a2 KO mice fed high fat diet
Completed20
21884Gerald I. Shulman
Longer vs shorter fast clamp
Completed117
18587Jon Ramsey
Measurement of energy expenditure, RER and body composition in 12 month old mice placed on one of 3 diets(control (AIN93G), ketogenic (90% fat, 10% protein, 0.7% carbohydrate), or low carb (70%fat, 20% protein, 10% carbohydrate)) for 1 month.
Completed620
20726Jon Ramsey
Measurement of energy expenditure, RER and body composition in 28 month old mice on one of 3 diets (control (AIN93G), ketogenic, or low carbohydrate diets for 1 year.
Completed391
16437Wencheng Li
Metabolic measurements in B6 mice fed high fat diet
Completed45
21864Jin Shengkan
Metabolic measurements in B6 mice treated with metformin and niclosamide
Completed96
21835Karen Ryan
Metabolic measurements in C57 mice on protein restricted diets
Completed128
21861Karen Ryan
Metabolic measurements in C57 mice treated with FGF21
Completed76
20730Jin Shengkan
Metabolic measurements in HFD fed B6 mice treated with niclosamide and metformin
Completed160
22067Jon Ramsey
Metabolic measurements in p65Schc -/- mice
Completed868
19696Kei Sakamoto
Metformin clamp Order #19696, April 2015
Completed8462
18482Carlos Fernandez-Hernando
miR33 KO clamp
Completed234
13195Owen McGuinness
MMPC Energy Balance Study Order #13195 7/17/14
Completed525
16422Jon Ramsey
Muscle TG levels in Shc KO mice
Completed24
1621Romina Fiorotto
Notch2 is required for proper IHBD development and morphogenesis.
Completed111
21908Natalie Torok
NOX4 LKO clamps
Completed234
2577Jonathan Schoenecker
Oxymax Order #2577 6/28/12
Completed66
3629David Wasserman
Oxymax Part 1 Order #3629 10/17/12
Completed310
3629David Wasserman
Oxymax Part 2 Order #3629 10/17/12
Completed296
3617Carl Johnson
Oxymax/Black Box (Altered Light Dark Period) Order #3617 10/1/12
Completed88
7711John Stafford
Oxymax/Treadmill Max Test Order #7711 2/19/13
Completed104
1997Saptarsi Haldar
Oxymax/Treadmill Order #1997 8/13/10
Completed2935
13264John Rutledge
Plasma metabolomics in non-fasted control and Western diet fed WT and LDLRKO mice
Completed40
21976Karen Ryan
Plasma TG and TC levels in FGF-21 treated C57 mice
Completed72
7840Owen McGuinness
Ppar/Sable/GTT Order #7840 6/10/13
Completed3369
21814Owen McGuinness
Sable Energy Balance # 21814 10/1/15
Completed224
21820Leslie Crofford
Sable Energy Balance # 21820 10/19/15
Completed1078
22069Richard Simerly
Sable Energy Balance # 22069 12/5/16
Completed208
18576Matthew Robinson
Sable Energy Balance #18576 1/4/16
Completed560
21750David Wasserman
Sable Energy Balance #21750 4/13/15
Completed192
21752Italo Biaggioni
Sable Energy Balance #21752 1/18/16
Completed156
21809Owen McGuinness
Sable Energy Balance #21809 2/18/15
Completed576
21814Owen McGuinness
Sable Energy Balance #21814 8/28/15
Completed192
22023David Wasserman
Sable Energy Balance #22023 6/16/16
Completed1820
22039Richard Simerly
Sable Energy Balance #22039 9/8/16
Completed156
22044Xin Jie Chen
Sable Energy Balance #22044 9/19/16
Completed224
22069Richard Simerly
Sable Energy Balance #22069 10/14/16
Completed52
22076Anna Hemnes
Sable Energy Balance #22076 9/26/16
Completed532
22085John Stafford
Sable Energy Balance #22085 10/21/16
Completed336
22097David Wasserman
Sable Energy Balance #22097 11/14/16
Completed392
22123Richard Simerly
Sable Energy Balance #22123 12/19/16
Completed392
22180John Stafford
Sable Energy Balance #22180 3/6/17
Completed224
22216Anna Hemnes
Sable Energy Balance #22216 3/13/17
Completed210
22223Alyssa Hasty
Sable Energy Balance #22223 3/27/17
Completed224
22233Sophia Yu
Sable Energy Balance #22233 4/3/17
Completed224
22382Daniel Lark
Sable Energy Balance #22382 7/19/17
Completed448
22398Steffen Daub
Sable Energy Balance #22398 10/9/17
Completed224
24532Jacob Brown
Sable Energy Balance #24532 3/16/18
Completed224
25601Sarah Davis
Sable Energy Balance #25601 1/29/18
Completed448
18484David Wasserman
Sable Energy Balance 2/23/15 #18484
Completed288
18495David Jacobson
Sable Energy Balance 3/2/15 #18495
Completed192
13097Weiqin Chen
Sable Energy Balance 8/25/14 #13097
Completed156
7705David Wasserman
SABLE Order #7705 2/7/13
Completed154
7716John Stafford
SABLE Order #7716 2/21/13
Completed132
7752David Wasserman
Sable Order #7752 3/28/13
Completed142
20727Helen Raybould
Sex differences in energy expenditure, meal patterns, and body composition in response to short term high fat diet (4 weeks)
Completed1550
1758Ming-Zhi Zhang
Tail Cuff Blood Pressure Order #1758 9/24/09
In Progress100
1788Richard Breyer
Tail Cuff Blood Pressure Order #1788 11/11/09
Completed60
3650Patty Lee
Ucp2 KO hypoxia CLAMS
Completed54
22379David Mills
Understanding the effects of prebiotic 2-Fucosyl-Lactose on gut permeability and plasma LBP
Completed216




PublicationAltmetricsSubmitted ByPubMed IDStatus
Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice.
McGavigan AK, Henseler ZM, Garibay D, Butler SD, Jayasinghe S, Ley RE, Davisson RL, Cummings BP
Disease models & mechanisms, 2017 (10), 235 - 243
Submitted Externally
28093508
Published
Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability and microbial dysbiosis in high-fat fed mice.
Hamilton MK, Ronveaux CC, Rust BM, Newman JW, Hawley M, Barile D, Mills DA, Raybould HE
American journal of physiology. Gastrointestinal and liver physiology, 2017, ajpgi.0042
Submitted Externally
28280143
Published


External References
NameLink to Reference
Mouse Phenome Database: StrainsClick to view

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