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Experiment

Examine effect of maternal DDT exposure on energy expenditure in
temperature-challenged female mice.
Summary Data Summary
Investigator La Merrill, Michele
Description While less of a problem in the USA, exposure to the pesticide
4,4'-dichlorodiphenyltrichloroethane (DDT) due to environmental contamination
and in regions where DDT continues to be used extensively for malaria control,
or were born prior to its ban elsewhere is still a major health concern. The
goal of this study is to understand the possible contribution of DDT to
metabolic syndrome.

Female C57BL/6J mice (15) whose mothers were treated with either Vehicle (oil)
or DDT (1.7mg/kg, po,14 days) had their energy expenditure assessed by high
resolution indirect calorimetry while subjected to a range of environmental
temperatures (12, 18, 24, 28, 30, 32, 34 and 36°C) as well as core body
temperature measured by IP implanted temperature recorder.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 8/29/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals15
Experimental Conditions3
Catalog Items1
Curation Info (# flags)2
Phenotype Assays11
Phenotype Measurements42977
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
15
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Experimental Group

 Mother injected with DDT
The mother of this animal was injected with DDT
 Mother injected with Oil
The mother of this animal was injected with oil

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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