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Experiment

Circulating leptin levels in Lep KO mice treated with leptin
Summary Data Summary
Investigator Murphy, William
Description We are also comparing mice deficient in leptin to those knockout mice given
leptin intraperitoneally. Diets given are D12450J 10% energy from fat, and
D12492 60% energy from fat for the wild-type C57Bl/6 mice. And 2918 18% energy
from fat chow diet for the ob/ob mice.

Injections were 1ug/kg, twice a day.

Applicable research area(s): Obesity
Status Completed
Public Release 6/14/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountExperiment Description
Data Analysis
TypeCount
Animals15
Experimental Conditions9
Catalog Items1
Curation Info (# flags)3
Phenotype Assays1
Phenotype Measurements15
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
9
0
ob/ob
0
6
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Leptin
Leptin administered
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 IP
The drug was delivered intraperitoneal.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 µg/kg BID
micrograms per kilograms twice per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Research Diets - D12450J
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)


Phenotype Assays Add / Edit



No documents found.

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