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Experiment

Circulating insulin and adiponectin levels in B6 mice treated with letrozole
Summary Data Summary
Investigator Thackray, Varykina
Description Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype.

Female mice with either Placebo or Letrozole pellets implants (5 weeks) were
fasted for 5 hrs starting at 8am and euthanized using isoflurance overdose.
Blood was collected via a 25G needle through the mouse aorta. Blood is tend
processed at 4C and spun down for serum. The objective of this study is to
obtain data regarding insulin and LBP levels in fasted placebo and letrozole
mice. To determine the difference in insulin response from the incretin effect
and determine whether letrozole affects the secretion of adiponectin.
Status Completed
Public Release 7/27/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals44
Experimental Conditions9
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements88
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
22
0
0
C57BL/6N
22
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 SC
The drug was delivered subcutaneously.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Teklad - 7004
Rodent diet with 29% kcal fat, 51% kcal carbohydrate, 20% kcal protein

Experimental Factor: Tissue Source

 serum
serum


Phenotype Assays Add / Edit



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