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Experiment

Circulating insulin and leptin levels in B6 mice fed high fat diet treated with
ShK-186
Summary Data Summary
Investigator kumar, sanjeev
Description C57BL6/J mice aged 8–9 wk were obtained from Harlan Laboratories and started on
Teklad TD.88137 together with 60% fructose/water (wt/vol) available ad libitum.
A second group was fed Teklad 7001 chow. ShK-186 was administered by s.c.
injection every other day at two doses 500ug/kg and 20ug/kg.

Applicable research area(s): Diabetes, Obesity
Status Completed
Public Release 3/12/2015
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals33
Experimental Conditions8
Catalog Items2
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements66
Histology Images0
Publications0
Documents1
Phenotypes1


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
33
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 ShK-186
Stichodactyla toxin that is a selective and potent blocker of the voltage-gated Kv1.3 channel
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 µg/kg every other d
micrograms per kilograms every other day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Teklad - 7001
Rodent diet with 13% kcal fat, 53% kcal carbohydrate, 34% kcal protein
 Teklad - 88137 plus 60% fructose solution
Harlan Teklad TD.88137 (Western Diet) plus a 60% fructose water (w/v) solution

Experimental Factor: Tissue Source

 serum
serum


Phenotype Assays Add / Edit


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