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Publication
Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation.
Authors Lee J, Choi J, Scafidi S, Wolfgang MJ
Submitted By Submitted Externally on 8/1/2018
Status Published
Journal Cell reports
Year 2016
Date Published 6/28/2016
Volume : Pages 16 : 201 - 212
PubMed Reference 27320917
Abstract The liver is critical for maintaining systemic energy balance during starvation.
To understand the role of hepatic fatty acid ß-oxidation on this process, we
generated mice with a liver-specific knockout of carnitine palmitoyltransferase
2 (Cpt2(L-/-)), an obligate step in mitochondrial long-chain fatty acid
ß-oxidation. Fasting induced hepatic steatosis and serum dyslipidemia with an
absence of circulating ketones, while blood glucose remained normal. Systemic
energy homeostasis was largely maintained in fasting Cpt2(L-/-) mice by
adaptations in hepatic and systemic oxidative gene expression mediated in part
by Ppara target genes including procatabolic hepatokines Fgf21, Gdf15, and
Igfbp1. Feeding a ketogenic diet to Cpt2(L-/-) mice resulted in severe
hepatomegaly, liver damage, and death with a complete absence of adipose
triglyceride stores. These data show that hepatic fatty acid oxidation is not
required for survival during acute food deprivation but essential for
constraining adipocyte lipolysis and regulating systemic catabolism when glucose
is limiting.








Genes
SymbolDescription
Cpt2carnitine palmitoyltransferase 2

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