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Strain
B6.129P2-Ptger3tm1Sna

Summary Data Summary
Official Name B6.129P2-Ptger3tm1Sna
Common Name EP3-
Description A lacZ-neomycin resistance cassette replaced 1kb of sequence
containing almost all of exon 1, which encodes the region of
the receptor from the amino terminus to the sixth
transmembrane domain. Northern blots of renal tissue did not
detect message in homozygous mutant mice. In addition, the
mutation was confirmed functionally, by lack of detectable
binding of [3H]-PGE2.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Richard BreyerVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Ptger3knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility.
Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian X, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD, Wang N, Zhu Y, Huang Y, Breyer RM, Guan Y
Arteriosclerosis, thrombosis, and vascular biology, 2012 (32), 3024 - 32
Submitted Externally
23065824
Published

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