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Strain
C57BL/6-Ube3atm1Alb/+

Summary Data Summary
Official Name C57BL/6-Ube3atm1Alb/+
Common Name C57BL/6-Ube3a+/-
Description Ubiquitin protein ligase E3A (Ube3a) heterozygous deletion
on C57Bl/6 background

A 3kb genomic region including exon 2 was replaced with a
neo-loxP-hprt cassette via homologous recombination,
resulting in deletion of 100 N-terminal amino acids in the
encoded protein and a frameshift inactivating all putative
protein isoforms. Homozygous mutant animals were identified
by Southern blot and PCR genotype analysis.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Carl JohnsonVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Ube3aknockoutwildNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Ube3a imprinting impairs circadian robustness in angelman syndrome models.
Shi SQ, Bichell TJ, Ihrie RA, Johnson CH
Current biology : CB, 2015 (25), 537 - 545
25660546
Published

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