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Strain
C57BL/6-Ncor1tm1.1Mlpr

Summary Data Summary
Official Name C57BL/6-Ncor1tm1.1Mlpr
Common Name NCoR omega
Description NCoR-omega and NCoR-delta share a splice acceptor but
utilize two distinct splice donors. Splice-specific NCoR
knockout mice were generated by the Mouse Biology Program at
the University of California at Davis (UC Davis). The
NCoR-omega splice donor was inactivated by site-directed
mutagenesis in mice without disrupting the NCoR-delta splice
donor or the NCoR-delta protein sequence to generate
NCoR-omega -/- mice.

The targeting construct encompassing exons 34 to 41
introduced a GT to CC mutation that ablates the 5' donor
site required for splicing of the omega isoform.
Flp-mediated recombination removed the FRT-flanked neomycin
resistance cassette within intron 37. The delta isoform is
not affected.
Development Status Phenotyping ongoing
Creation Method congenic
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 5
Publications 1


Investigators
NameInstitution
Martin PrivalskyUniversity of California Davis


Genomic Information
GeneAllele 1Allele 2Protocol
Ncor1knockoutwildNot Specified


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