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Experiment

Gross body composition and Energy expenditure in Ncor1D (Ncor1-omega KO) mice
Summary Data Summary
Investigator Privalsky, Martin
Description NCoR is subject to alternative mRNA splicing, yielding a series of distinct
corepressor variants with highly divergent functions. Normal adipogenesis is
associated with a switch in corepressor splicing from NCoRomega to NCoRdelta,
which appears to help regulate this differentiation process. We wish to test the
effect of mimicking this development switch in mice by a splice-specific
whole-animal ablation of NCoR-omega. We wish to examine the effect on energy
expenditure and body composition.
Status Completed
Public Release 2/14/2015
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals18
Experimental Conditions2
Catalog Items1
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements496
Histology Images0
Publications0
Documents2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
11
0
NCoR omega
0
7
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
Experimental Factor (Units)
Experimental Group
Mouse Diet


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