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Strain
C57BL/6-Ikbkbtm2Mka Tg(Pdgfrb-cre)#Rha

Summary Data Summary
Official Name C57BL/6-Ikbkbtm2Mka Tg(Pdgfrb-cre)#Rha
Common Name C57BL/6-Ikbkbtm2Mka Tg(Pdgfrb-cre)#Rha
Description Conditional KO of Ikbkb in adipose tissue. Homozygotes for
targeted null mutations exhibit liver degeneration and die
in midgestation. Conditional mutations that lack gene
expression in lymphoid cells or epidermal keratinocytes
exhibit B and T cell deficits and skin inflammation,
respectively.

To delete IKKß in adipocyte lineage cells, mice containing
loxP-flanked IKKß alleles (IKKß fl/fl) were crossed with
PDGFRß-Cre transgenic mice to generate PDGFRß-Cre/IKKß fl/fl
mice
Development Status Phenotyping ongoing
Creation Method knockin
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Publications 1


Investigators
NameInstitution
Changcheng ZhouUniversity of Kentucky


Genomic Information
GeneAllele 1Allele 2Protocol
Ikbkbknockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedPdgfrbCRENot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Targeting I?B kinase ß in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions.
Helsley RN, Sui Y, Park SH, Liu Z, Lee RG, Zhu B, Kern PA, Zhou C
Stem cells (Dayton, Ohio), 2016 (34), 1883 - 95
Submitted Externally
26991836
Published

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