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Strain
B6.129-Scd1tm1Ntam/J

Summary Data Summary
Official Name B6.129-Scd1tm1Ntam/J
Common Name Scd1 global KO
Description The entire coding region of the gene (exons 1-6) was
replaced with a neomycin resistance cassette via homologous
recombination. Absence of gene expression in homozygous
mutant animals was confirmed by Northern blot analysis of
various tissue samples and by Western blot analysis of liver
protein extracts. Enzyme activity was also undetectable in
liver extracts from homozygous animals.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Phenotype Description Mice with a deletion of the ?(9)-desaturase-1 isoform (SCD1)
globally (Scd1(-/-)) present with marked changes in
cutaneous lipids and skin integrity. Interestingly, these
mice also exhibit increased whole body energy expenditure,
protection against diet-induced adiposity, hepatic
steatosis, and glucose intolerance.
TypeCount
Investigators 1
Genomics - Modifications 1
Publications 1


Investigators
NameInstitution
James NtambiUniversity of Wisconsin-Madison


Genomic Information
GeneAllele 1Allele 2Protocol
Scd1knockoutknockoutNot Specified




PublicationAltmetricsSubmitted ByPubMed IDStatus
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.
Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM
The Journal of biological chemistry, 2009 (284), 19961 - 73
Submitted Externally
19429677
Published

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