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Publication
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid
composition and protects mice from high fat diet-induced obesity.
Authors Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM
Submitted By Submitted Externally on 9/20/2017
Status Published
Journal The Journal of biological chemistry
Year 2009
Date Published 7/24/2009
Volume : Pages 284 : 19961 - 73
PubMed Reference 19429677
Abstract Stearoyl-CoA desaturase-1 (SCD1) catalyzes the synthesis of monounsaturated
fatty acids and is an important regulator of whole body energy homeostasis.
Severe cutaneous changes in mice globally deficient in SCD1 also indicate a role
for SCD1 in maintaining skin lipids. We have generated mice with a skin-specific
deletion of SCD1 (SKO) and report here that SKO mice display marked sebaceous
gland hypoplasia and depletion of sebaceous lipids. In addition, SKO mice have
significantly increased energy expenditure and are protected from high fat
diet-induced obesity, thereby recapitulating the hypermetabolic phenotype of
global SCD1 deficiency. Genes of fat oxidation, lipolysis, and thermogenesis,
including uncoupling proteins and peroxisome proliferator-activated
receptor-gamma co-activator-1alpha, are up-regulated in peripheral tissues of
SKO mice. However, unlike mice globally deficient in SCD1, SKO mice have an
intact hepatic lipogenic response to acute high carbohydrate feeding. Despite
increased basal thermogenesis, SKO mice display severe cold intolerance because
of rapid depletion of fuel substrates, including hepatic glycogen, to maintain
core body temperature. These data collectively indicate that SKO mice have
increased cold perception because of loss of insulating factors in the skin.
This results in up-regulation of thermogenic processes for temperature
maintenance at the expense of fuel economy, illustrating cross-talk between the
skin and peripheral tissues in maintaining energy homeostasis.




Strains
StrainDevelopment StatusCreation MethodOptions
B6.Cg-Scd1tm2Ntam Tg(KRT14-cre)1AmcPhenotyping ongoingknockout
View
B6.129-Scd1tm1Ntam/JPhenotyping ongoingknockout
View




Genes
SymbolDescription
Scd1stearoyl-Coenzyme A desaturase 1

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