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Experiment

Pilot study
Summary Data Summary
Investigator Adams, Sean
Description Determine the effect of HFD (45% kcal fat diet ) on energy expenditure at
standard vivarium temperature (20°C) in addition to thermal neutral (30°C) and
cold challenge (10°C). This will be evaluated in high and low weight gaining
animals (upper and lower quartile) on a high fat diet in comparison to those fed
a low-fat diet.

Applicable research area(s): Cardiovascular, Diabetes, Metabolism
Status Completed
Public Release 8/24/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals24
Experimental Conditions4
Catalog Items7
Curation Info (# flags)2
Phenotype Assays31
Phenotype Measurements2232
Histology Images0
Publications0
Phenotypes9


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6N
0
24
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 08510
10% Fat Kcal Diet (ISP) -- The control diet in a series of diets with isolated soy protein, 10, 45, or 60% kcal from fat, with ~43% of the total carbohydrate from sucrose, and equivalent vitamin and mineral levels adjusted on an energy basis....
 Teklad - 08511
45% Fat Kcal Diet (ISP) -- The mid-fat diet in a series of diets with isolated soy protein, 10, 45, or 60% kcal from fat, with ~43% of the total carbohydrate from sucrose, and equivalent vitamin and mineral levels adjusted on an energy basis....

Experimental Factor: Phenotype Quartile

 0-25
lower quartile
 75-100
upper quartile
 ND
Not Done



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001260increased body weight
greater than normal average weight [J:33400]
MMPC Search Results
MP:0005458increased percent body fat/body weight
more fat| relative to controls| expressed as a percentage of total body weight [MGI:cwg]
MMPC Search Results
MP:0008964decreased carbon dioxide production
reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010024increased total body fat amount
greater than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0010123increased bone mineral content
elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area [MGI:csmith]
MMPC Search Results
MP:0010379decreased respiratory quotient
reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0010967increased compact bone area
increase in the total amount of cross-sectional area of compact bone tissue [MGI:csmith]
MMPC Search Results
MP:0011939increased food intake
increase in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0014024increased subchondral bone mineral content
increased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces [MGI:csmith| PMID:20392241]
MMPC Search Results

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