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Experiment

Energy utilization and body composition of Nav1.8-LepR (fl/fl) mice (knockout of
LepR in sensory neurons)
Summary Data Summary
Investigator Raybould, Helen
Description We are testing the hypothesis that leptin resistance in vagal afferent neurons
(VAN) specifically is responsible for the onset of hyperphagia in LepR KO mice.
This study will examine energy expenditure, food intake/patterns, and body
composition (DEXA) in mice with a novel conditional knockout mouse deleting
leptin receptor selectively in sensory neurons (Nav1.8/LepRfl/fl mice).
Status Completed
Public Release 2/12/2015
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals16
Experimental Conditions2
Catalog Items1
Curation Info (# flags)0
Phenotype Assays20
Phenotype Measurements496
Histology Images0
Publications0
Documents3


Animals

Strain NameCommon NameFemalesMalesUnknown
LepRflox
4
4
0
Nav1.8-LepR(fl/fl)
4
4
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet 5058
PicoLab Mouse Diet 20, 20.0% protein (Calories: 23% protein, 22% Fat, 55% Carbohydrate)
Experimental Factor (Units)
Experimental Group
Mouse Diet


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