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Experiment

Effect of antibiotics on energy expenditure in Ob/Ob and C57BL/6J (WT) mice
Summary Data Summary
Investigator Knotts, Trina
Description Deletion of leptin in the Ob/Ob mouse (B6.Cg-Lep/J) produces a deleterious
metabolic phenotype. Mice are obese with many of the deleterious effects of
obesity (hyperphagia, transient hyperglycemia, glucose intolerance, elevated
plasma insulin, hypometabolic, and hypothermic) independent of a high fat,
high-energy diet.

Energy expenditure will be assessed by indirect calorimetry in C57BL6/J (WT) and
Ob/Ob mice treated with antibiotics (water, 1g/L Neomycin+ 0.5g/L Vancomycin, or
0.5g/L Cefoperazone) in drinking water.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 6/5/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagNo Experimental Group
Data Analysis
TypeCount
Animals49
Experimental Conditions5
Catalog Items4
Curation Info (# flags)1
Phenotype Assays23
Phenotype Measurements1127
Histology Images0
Publications0
Phenotypes10


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
24
0
B6.Cg-Lepob/J
0
25
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Cefaperazone
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
 Vancomycin, Neomycin
0.5 g/L Vancomycin and 1.0 g/L Neomycin combination
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 g/L
grams per liter

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001260increased body weight
greater than normal average weight [J:33400]
MMPC Search Results
MP:0001402hypoactivity
general reduced locomotor activity; reduced movement from one place to another or having a decreased state of activity [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0005202lethargy
mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction [ISBN:0-683-40008-8]
MMPC Search Results
MP:0005290decreased oxygen consumption
less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body [MESH:G06.535.723]
MMPC Search Results
MP:0008964decreased carbon dioxide production
reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010378increased respiratory quotient
increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0011939increased food intake
increase in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0011945increased eating frequency
increase in the number of discrete instances of initiation of eating over time| regardless of amount eaten [MGI:csmith]
MMPC Search Results
MP:0012344decreased gnawing activity
decreased biting or chewing on something [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results
MP:0020211slow movement
decreased rate or speed of the coordinated movements executed with a purpose [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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