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Experiment

Effects of Ryanadine receptor hemizygosity on energy expenditure with running
wheel
Summary Data Summary
Investigator Pessah, Isaac
Description Mutations in Either type 1 receptor (RyR1) or the dihydropyridine
receptorsubunit Cav1.1 cause malignant hyperthermia susceptiblity (MHS) in
humans and animals. It is necessary to understand how altered RyR1 channel
regulation influences baal changes in mitochondrial bioenergetics, produces
oxidative stress and promotes progressive muscle change. This study is a
follow-up study to the running wheel study done in male and female mice (WT and
HET). Here, energy expenditure (by indirect calorimetry) and core temperature
readings are assessed while allowed access to voluntary running wheels at two
environmental temperatures (22 and 28 C). This will allow us to better
characterize how ambient temperature influences heat stress in MHS mice females
when compared to males.

Applicable research area(s): Metabolism
Status Completed
Public Release 1/9/2021
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals30
Experimental Conditions4
Catalog Items3
Curation Info (# flags)0
Phenotype Assays37
Phenotype Measurements22200
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
8
7
0
RyR1-R163C
8
7
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Light-Dark Period

 Dark
The Dark period
 Light
The light period

Experimental Factor: Wheel Running (day)

 Wheel Running
The numerical day on which the wheel running measurement was collected.



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