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Experiment

Oxymax/Treadmill Order #1997 8/13/10
Summary Data Summary
Investigator Haldar, Saptarsi
Description Klf15 is important for: (1) cardiac and vascular response to stress, (2) hepatic
gluconeogenesis, (3) skeletal muscle and cardiac muscle metabolism

Klf15 KO mice have defects in skeletal and cardiac beta oxidation in vivo. Klf15
KO mice have reduced capacity for endurance exercise and isolated skeletal
muscle is more fatiguable. In addition to beta oxidation defects, there may be
defects in fatty acid uptake in vivo as well. There is no difference in basal
energy expenditure as assessed by indirect calorimetry. However, we hypothesize
that there will be abnormalities in energy utilization with exercise. We wish to
perform exercise metabolic studies and fatty-acid uptake studies in our Klf15 KO
mice at the Vanderbilt core.

Applicable research area(s): Human Disease, Metabolism, Cardiovascular
Status Completed
Public Release 8/22/2014
Animal Age Measured In: day(s) post-natal (d)
Flags has-data-flagSame StrainMetadataNo dataExperiment Description
Data Analysis
TypeCount
Animals23
Experimental Conditions3
Catalog Items3
Curation Info (# flags)4
Phenotype Assays25
Phenotype Measurements2935
Histology Images0
Publications0
Phenotypes3


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
10
0
C57BL/6J-Klf15-/-
0
13
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Time Sample Taken (min)

 Time Sample Taken
Time in minutes since a sample was taken

Experimental Factor: Treadmill Speed (m/min)

 Treadmill_Speed
The speed of the treadmill used during an energy expenditure experiment



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